ea0029oc15.6 | Thyroid Basic | ICEECE2012
Akama T.
, Hara T.
, Yan D.
, Kawashima A.
, Yoshihara A.
, Sue M.
, Tanigawa K.
, Wu H.
, Ishido Y.
, Ishii N.
, Suzuki K.
Introduction: Thyroglobulin (Tg) is stored in the follicular lumen of the thyroid and serves as a substrate of thyroid hormone biosynthesis. However, it was shown that Tg significantly induces thyrocyte cell growth and suppresses expression of thyroid-functional genes. Despite having such functions, molecular mechanisms of Tg action are largely unclear. We have recently demonstrated that TSH-induced thyroid cell growth is partly mediated by a downregulation of microRNAs (miRNA...